What does the Celiac Disease Panel (TtG) - TtG blood test mean? Get a free analysis of your blood test now. Here's what you get with our free analysis:
The Celiac Disease Panel, specifically the Tissue Transglutaminase (TtG) test, is used to screen for celiac disease, an autoimmune disorder triggered by gluten consumption. This test measures antibodies produced against the TtG enzyme, which is found in many tissues and is involved in the inflammatory process of celiac disease. It is highly sensitive and specific for celiac disease diagnosis. A positive result may indicate the presence of celiac disease, but further testing, including intestinal biopsy, is often required for definitive diagnosis. This test is particularly useful for monitoring adherence to a gluten-free diet in diagnosed patients, as antibody levels typically decrease with strict gluten avoidance.
A TtG result below the lower range is generally considered negative for celiac disease. This suggests that the body is not producing significant amounts of antibodies against tissue transglutaminase, which is typically seen in celiac disease. However, it’s important to note that a negative result does not completely rule out celiac disease, especially in early stages or in individuals already following a gluten-free diet. Clinical symptoms and other diagnostic methods should be considered for a comprehensive evaluation.
A TtG result above the upper range is considered positive and strongly suggests celiac disease. This indicates that the body is producing elevated levels of antibodies against tissue transglutaminase, which is characteristic of celiac disease. However, a positive result alone is not sufficient for diagnosis. Further testing, including intestinal biopsy, is typically recommended to confirm the diagnosis. In diagnosed patients, high TtG levels may indicate poor adherence to a gluten-free diet or ongoing intestinal damage. Consultation with a healthcare provider is essential for proper interpretation and management.