What does the Cyclic Citrullinated Peptide Antibody - CCP blood test mean? Get a free analysis of your blood test now. Here's what you get with our free analysis:
The Cyclic Citrullinated Peptide Antibody (CCP) test is used to detect the presence of anti-CCP antibodies in the blood. These antibodies are specific markers for rheumatoid arthritis (RA), an autoimmune disease that causes inflammation and joint damage. The test is particularly useful in early diagnosis of RA, even before clinical symptoms appear. It has high specificity for RA, meaning a positive result is strongly indicative of the disease. The CCP test is often used in conjunction with other tests, such as rheumatoid factor, to improve diagnostic accuracy. It can also help predict the severity and progression of RA, as higher levels of anti-CCP antibodies are associated with more aggressive disease.
A CCP antibody level below the lower range limit (< 0 U/mL) is considered negative. This typically indicates that the individual does not have rheumatoid arthritis (RA) or that the likelihood of developing RA is low. However, it’s important to note that some people with RA may still test negative for CCP antibodies, especially in early stages of the disease. Therefore, a negative result does not completely rule out RA, and other clinical factors and tests should be considered for a comprehensive diagnosis.
A CCP antibody level above the upper range limit (> 5 U/mL) is considered positive and strongly suggests the presence of rheumatoid arthritis (RA). Higher levels of anti-CCP antibodies are associated with more severe disease and a higher risk of joint damage. A positive result, especially when combined with clinical symptoms and other test results, can lead to earlier diagnosis and treatment of RA. However, it’s important to note that some individuals may have elevated CCP antibodies without developing RA, and the test should be interpreted in the context of other clinical findings.