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Adrenocorticotropic Hormone (ACTH) - ACTH

What does the Adrenocorticotropic Hormone (ACTH) - ACTH blood test mean? Get a free analysis of your blood test now. Here's what you get with our free analysis:

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The ACTH test measures the level of adrenocorticotropic hormone in the blood. ACTH is produced by the pituitary gland and stimulates the adrenal glands to produce cortisol. This test is used to diagnose disorders of the pituitary or adrenal glands, such as Cushing's syndrome, Addison's disease, or pituitary tumors. It can also help differentiate between primary and secondary adrenal insufficiency. ACTH levels fluctuate throughout the day, typically being highest in the morning and lowest at night, so the timing of the test is important for accurate interpretation.

Acceptable Range:   7 to 46
Ideal for Women:   10-50
Ideal for Men:   10-50
Ideal for Girls:   10-50
Ideal for Boys:   10-50
Test Method: Blood test

What do readings below 7 pg/mL for Adrenocorticotropic Hormone (ACTH) - ACTH mean?

A low ACTH level may indicate:

  • Secondary adrenal insufficiency (pituitary gland not producing enough ACTH)
  • Cushing’s syndrome caused by an adrenal tumor
  • Use of corticosteroid medications
  • Hypopituitarism (underactive pituitary gland)

Low ACTH can lead to insufficient cortisol production, potentially causing fatigue, weakness, weight loss, and low blood pressure. Further testing may be needed to determine the underlying cause and appropriate treatment.

What do readings above 46 pg/mL for Adrenocorticotropic Hormone (ACTH) - ACTH mean?

An elevated ACTH level may indicate:

  • Primary adrenal insufficiency (Addison’s disease)
  • Congenital adrenal hyperplasia
  • Cushing’s disease (pituitary tumor producing excess ACTH)
  • Ectopic ACTH syndrome (non-pituitary tumor producing ACTH)
  • Stress or severe illness

High ACTH can lead to excessive cortisol production, potentially causing weight gain, muscle weakness, high blood pressure, and mood changes. Additional tests are usually required to determine the specific cause and appropriate treatment plan.

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